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Journal of Biomedical Optics

Hybridized wavefront shaping for high-speed, high-efficiency focusing through dynamic diffusive media
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Paper Abstract

One of the prime limiting factors of optical imaging in biological applications is the diffusion of light by tissue, which prevents focusing at depths greater than the optical diffusion limit (typically ∼1  mm). To overcome this challenge, wavefront shaping techniques that use a spatial light modulator (SLM) to correct the phase of the incident wavefront have recently been developed. These techniques are able to focus light through scattering media beyond the optical diffusion limit. However, the low speeds of typically used liquid crystal SLMs limit the focusing speed. Here, we present a method using a digital micromirror device (DMD) and an electro-optic modulator (EOM) to measure the scattering-induced aberrations, and using a liquid crystal SLM to apply the correction to the illuminating wavefront. By combining phase modulation from an EOM with the DMD’s ability to provide selective illumination, we exploit the DMD’s higher refresh rate for phase measurement. We achieved focusing through scattering media in less than 8 ms, which is sufficiently short for certain in vivo applications, as it is comparable to the speckle correlation time of living tissue.

Paper Details

Date Published: 14 September 2016
PDF: 6 pages
J. Biomed. Opt. 21(12) 121502 doi: 10.1117/1.JBO.21.12.121502
Published in: Journal of Biomedical Optics Volume 21, Issue 12
Show Author Affiliations
Ashton S. Hemphill, Washington Univ. in St. Louis (United States)
Jian Wei Tay, Washington Univ. in St. Louis (United States)
Lihong V. Wang, Washington Univ. in St. Louis (United States)

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