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Journal of Biomedical Optics

In vivo super-resolution retinal imaging through virtually structured detection
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Paper Abstract

High resolution is important for sensitive detection of subtle distortions of retinal morphology at an early stage of eye diseases. We demonstrate virtually structured detection (VSD) as a feasible method to achieve in vivo super-resolution ophthalmoscopy. A line-scanning strategy was employed to achieve a super-resolution imaging speed up to 127    frames / s with a frame size of 512 × 512    pixels . The proof-of-concept experiment was performed on anesthetized frogs. VSD-based super-resolution images reveal individual photoreceptors and nerve fiber bundles unambiguously. Both image contrast and signal-to-noise ratio are significantly improved due to the VSD implementation.

Paper Details

Date Published: 19 December 2016
PDF: 4 pages
J. Biomed. Opt. 21(12) 120502 doi: 10.1117/1.JBO.21.12.120502
Published in: Journal of Biomedical Optics Volume 21, Issue 12
Show Author Affiliations
Changgeng Liu, Univ. of Illinois at Chicago (United States)
Yanan Zhi, Univ. of Illinois at Chicago (United States)
Benquan Wang, Univ. of Illinois at Chicago (United States)
Damber Thapa, Univ. of Illinois at Chicago (United States)
Yanjun Chen, Univ. of Illinois at Chicago (United States)
Minhaj Alam, Univ. of Illinois at Chicago (United States)
Yiming Lu, Univ. of Illinois at Chicago (United States)
Xincheng Yao, Univ. of Illinois at Chicago (United States)


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