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Journal of Biomedical Optics • Open Access

Photoacoustic mammography capable of simultaneously acquiring photoacoustic and ultrasound images
Author(s): Yasufumi Asao; Yohei Hashizume; Takahiro Suita; Ken-ichi Nagae; Kazuhiko Fukutani; Yoshiaki Sudo; Toshikazu Matsushita; Shuichi Kobayashi; Mariko Tokiwa; Iku Yamaga; Elham Fakhrejahani; Masae Torii; Masahiro Kawashima; Masahiro Takada; Shotaro Kanao; Masako Kataoka; Tsuyoshi Shiina; Masakazu Toi

Paper Abstract

We have constructed a prototype photoacoustic mammography system (PAM-02) capable of simultaneously acquiring photoacoustic (PA) and ultrasound (US) images. Each PA, US, and fused PA/US image can be acquired over a wide area of the breast using the scanning module of a US transducer, a PA detector, and optical prisms. The resolution of the PA images exhibits improvement from 2 to 1 mm compared to images acquired using our previous prototype. The maximum scan area of PAM-02 is 90 mm along the horizontal axis and 150 mm along the vertical axis. In a phantom experiment, the available depth was at least 45 mm. A representative example of the application of the PAM-02 prototype in clinical research at Kyoto University is presented and shows S-factor images, which are considered an approximation parameter related to hemoglobin saturation of tumor-related blood vessels. We confirmed the applicability of the system for anatomical and biological research.

Paper Details

Date Published: 23 November 2016
PDF: 12 pages
J. Biomed. Opt. 21(11) 116009 doi: 10.1117/1.JBO.21.11.116009
Published in: Journal of Biomedical Optics Volume 21, Issue 11
Show Author Affiliations
Yasufumi Asao, Canon Inc. (Japan)
Kyoto Univ. (Japan)
Yohei Hashizume, Canon Inc. (Japan)
Takahiro Suita, Canon Inc. (Japan)
Ken-ichi Nagae, Canon Inc. (Japan)
Kazuhiko Fukutani, Canon Inc. (Japan)
Yoshiaki Sudo, Canon Inc. (Japan)
Toshikazu Matsushita, Canon Inc. (Japan)
Shuichi Kobayashi, Canon Inc. (Japan)
Mariko Tokiwa, Kyoto Univ. (Japan)
Iku Yamaga, Kyoto Univ. (Japan)
Elham Fakhrejahani, Kyoto Univ. (Japan)
Masae Torii, Kyoto Univ. (Japan)
Masahiro Kawashima, Kyoto Univ. (Japan)
Masahiro Takada, Kyoto Univ. (Japan)
Shotaro Kanao, Kyoto Univ. (Japan)
Masako Kataoka, Kyoto Univ. (Japan)
Tsuyoshi Shiina, Kyoto Univ. Graduate School of Medicine (Japan)
Masakazu Toi, Kyoto Univ. (Japan)

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