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Journal of Biomedical Optics • Open Access

Moving-source elastic wave reconstruction for high-resolution optical coherence elastography

Paper Abstract

Optical coherence tomography (OCT)-based elasticity imaging can map soft tissue elasticity based on speckle-tracking of elastic wave propagation using highly sensitive phase measurements of OCT signals. Using a fixed elastic wave source and moving detection, current imaging sequences have difficulty in reconstructing tissue elasticity within speckle-free regions, for example, within the crystalline lens of the eye. We present a moving acoustic radiation force imaging sequence to reconstruct elastic properties within a speckle-free region by tracking elastic wave propagation from multiple laterally moving sources across the field of view. We demonstrate the proposed strategy using heterogeneous and partial speckle-free tissue-mimicking phantoms. Harder inclusions within the speckle-free region can be detected, and the contrast-to-noise ratio slightly enhanced compared to current OCE imaging sequences. The results suggest that a moving source approach may be appropriate for OCE studies within the large speckle-free regions of the crystalline lens.

Paper Details

Date Published: 8 November 2016
PDF: 5 pages
J. Biomed. Opt. 21(11) 116006 doi: 10.1117/1.JBO.21.11.116006
Published in: Journal of Biomedical Optics Volume 21, Issue 11
Show Author Affiliations
Bao-Yu Hsieh, Univ. of Washington (United States)
China Medical Univ. (Taiwan)
Shaozhen Song, Univ. of Washington (United States)
Thu-Mai Nguyen, Univ. of Washington (United States)
Soon Joon Yoon, Univ. of Washington (United States)
Tueng T. Shen, Univ. of Washington (United States)
Ruikang K. Wang, Univ. of Washington (United States)
Matthew O'Donnell, Univ. of Washington (United States)

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