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Journal of Biomedical Optics

Separating melanin from hemodynamics in nevi using multimode hyperspectral dermoscopy and spatial frequency domain spectroscopy
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Paper Abstract

Changes in the pattern and distribution of both melanocytes (pigment producing) and vasculature (hemoglobin containing) are important in distinguishing melanocytic proliferations. The ability to accurately measure melanin distribution at different depths and to distinguish it from hemoglobin is clearly important when assessing pigmented lesions (benign versus malignant). We have developed a multimode hyperspectral dermoscope (SkinSpect™) able to more accurately image both melanin and hemoglobin distribution in skin. SkinSpect uses both hyperspectral and polarization-sensitive measurements. SkinSpect’s higher accuracy has been obtained by correcting for the effect of melanin absorption on hemoglobin absorption in measurements of melanocytic nevi. In vivo human skin pigmented nevi (N=20) were evaluated with the SkinSpect, and measured melanin and hemoglobin concentrations were compared with spatial frequency domain spectroscopy (SFDS) measurements. We confirm that both systems show low correlation of hemoglobin concentrations with regions containing different melanin concentrations (R=0.13 for SFDS, R=0.07 for SkinSpect).

Paper Details

Date Published: 10 November 2016
PDF: 11 pages
J. Biomed. Opt. 21(11) 114001 doi: 10.1117/1.JBO.21.11.114001
Published in: Journal of Biomedical Optics Volume 21, Issue 11
Show Author Affiliations
Fartash Vasefi, Spectral Molecular Imaging, Inc. (United States)
Nicholas MacKinnon, Spectral Molecular Imaging, Inc. (United States)
Rolf Saager, Beckman Laser Institute and Medical Clinic (United States)
Kristen M. Kelly, Beckman Laser Institute and Medical Clinic (United States)
Tyler Maly, Beckman Laser Institute and Medical Clinic (United States)
Nicholas Booth, Spectral Molecular Imaging, Inc. (United States)
Anthony J. Durkin, Beckman Laser Institute and Medical Clinic (United States)
Daniel L. Farkas, Spectral Molecular Imaging, Inc. (United States)
Univ. of Southern California (United States)


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