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Journal of Biomedical Optics

Ultrafast optical property map generation using lookup tables
Author(s): Joseph Angelo; Christina R. Vargas; Bernard T. Lee; Irving J. Bigio; Sylvain Gioux
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Paper Abstract

Imaging technologies working in the spatial frequency domain are becoming increasingly popular for generating wide-field maps of optical properties, enabling rapid analysis of tissue parameters. While acquisition methods have become faster and are now performing in real-time, processing methods remain slow, precluding real-time display of information. We present solutions that rapidly solve the inverse problem for extracting optical properties by use of advanced lookup tables (LUTs). We present methods and results based on a dense, linearly sampled lookup table and an analytical representation that generate maps of absorption and reduced scattering in ∼10  ms, which is 100× faster than the standard method, with ≤4% error compared to the Monte-Carlo simulation. Combined with real-time acquisition methods, the proposed techniques enable video-rate feedback of real-time property maps, enabling full video-rate guidance in the clinic.

Paper Details

Date Published: 30 November 2016
PDF: 4 pages
J. Biomed. Opt. 21(11) 110501 doi: 10.1117/1.JBO.21.11.110501
Published in: Journal of Biomedical Optics Volume 21, Issue 11
Show Author Affiliations
Joseph Angelo, Beth Israel Deaconess Medical Ctr. (United States)
Boston Univ. (United States)
Christina R. Vargas, Beth Israel Deaconess Medical Ctr. (United States)
Bernard T. Lee, Beth Israel Deaconess Medical Ctr. (United States)
Irving J. Bigio, Boston Univ. (United States)
Sylvain Gioux, Beth Israel Deaconess Medical Ctr. (United States)
Univ. de Strasbourg (France)

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