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Journal of Biomedical Optics

Isolated and combined effects of photobiomodulation therapy, topical nonsteroidal anti-inflammatory drugs, and physical activity in the treatment of osteoarthritis induced by papain
Author(s): Shaiane Silva Tomazoni; Ernesto Cesar Pinto Leal-Junior; Lúcio Frigo; Rodney Capp Pallotta; Simone Teixeira; Patrícia De Almeida; Jan Magnus Bjordal; Rodrigo Álvaro Brandão Lopes-Martins
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Paper Abstract

Osteoarthritis (OA) is a chronic inflammatory disease and is characterized as a degenerative process. This study aimed to evaluate and compare the effects of a topical nonsteroidal anti-inflammatory drug (NSAID), physical activity, and photobiomodulation therapy (PBMT) applied alone and/or in combination between them in an experimental model of knee OA. OA was induced by injection of papain in the knees of rats. After 21 days, the animals started to be treated with the above treatment. Histological analysis shows that the experimental model of OA induction causes morphological changes consistent with the disease, and among treatments, the PBMT is the most effective for reducing these changes. Moreover, the results demonstrate that PBMT and NSAID reduce the total number of cells in the inflammatory infiltrate (p<0.05) and PBMT was the most effective for reducing the activity of myeloperoxidase (p<0.05). Finally, we observed that both NSAID and PBMT were effective for reducing the gene expression of MMP-3 (p<0.05), but in relation to the gene expression of MMP-13, PBMT was the most effective treatment (p<0.05). The results of this study indicate that PBMT is the most effective therapy in stopping disease progression, and improving inflammatory conditions observed in OA.

Paper Details

Date Published: 18 October 2016
PDF: 7 pages
J. Biomed. Opt. 21(10) 108001 doi: 10.1117/1.JBO.21.10.108001
Published in: Journal of Biomedical Optics Volume 21, Issue 10
Show Author Affiliations
Shaiane Silva Tomazoni, Univ. de São Paulo (Brazil)
Ernesto Cesar Pinto Leal-Junior, Nove de Julho Univ. (Brazil)
Lúcio Frigo, UNICSUL (Brazil)
Rodney Capp Pallotta, Univ. of São Paulo (Brazil)
Simone Teixeira, Univ. de São Paulo (Brazil)
Patrícia De Almeida, Univ. of São Paulo (Brazil)
Jan Magnus Bjordal, Univ. of Bergen (Norway)
Rodrigo Álvaro Brandão Lopes-Martins, Univ. de Mogi das Cruzes (Brazil)
Univ. Camilo Castelo Branco (Brazil)


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