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Journal of Biomedical Optics

Toward laboratory blood test-comparable photometric assessments for anemia in veterinary hematology
Author(s): Taehoon Kim; Seung Ho Choi; Nathan Lambert-Cheatham; Zhengbin Xu; Janice E. Kritchevsky; Francois-René Bertin; Young L. Kim
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Paper Abstract

Anemia associated with intestinal parasites and malnutrition is the leading cause of morbidity and mortality in small ruminants worldwide. Qualitative scoring of conjunctival redness has been developed so that farmers can gauge anemia in sheep and goats to identify animals that require treatment. For clinically relevant anemia diagnosis, complete blood count-comparable quantitative methods often rely on complicated and expensive optical instruments, requiring detailed spectral information of hemoglobin. We report experimental and numerical results for simple, yet reliable, noninvasive hemoglobin detection that can be correlated with laboratory-based blood hemoglobin testing for anemia diagnosis. In our pilot animal study using calves, we exploit the third eyelid (i.e., palpebral conjunctiva) as an effective sensing site. To further test spectrometer-free (or spectrometerless) hemoglobin assessments, we implement full spectral reconstruction from RGB data and partial least square regression. The unique combination of RGB-based spectral reconstruction and partial least square regression could potentially offer uncomplicated instrumentation and avoid the use of a spectrometer, which is vital for realizing a compact and inexpensive hematology device for quantitative anemia detection in the farm field.

Paper Details

Date Published: 5 October 2016
PDF: 9 pages
J. Biomed. Opt. 21(10) 107001 doi: 10.1117/1.JBO.21.10.107001
Published in: Journal of Biomedical Optics Volume 21, Issue 10
Show Author Affiliations
Taehoon Kim, Purdue Univ. (United States)
Seung Ho Choi, Purdue Univ. (United States)
Nathan Lambert-Cheatham, Purdue Univ. (United States)
Zhengbin Xu, Purdue Univ. (United States)
Janice E. Kritchevsky, Purdue Univ. (United States)
Francois-René Bertin, The Univ. of Queensland (Australia)
Young L. Kim, Purdue Univ. (United States)
Kyung Hee Univ. (Korea, Republic of)


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