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Journal of Biomedical Optics • Open Access

<italic<In vivo</italic< deep tissue imaging using wavefront shaping optical coherence tomography
Author(s): Hyeonseung Yu; Peter Lee; KyeoReh Lee; Jaeduck Jang; Jaeguyn Lim; Wooyoung Jang; Yong Jeong; YongKeun Park

Paper Abstract

Multiple light scattering in tissue limits the penetration of optical coherence tomography (OCT) imaging. Here, we present <italic<in vivo</italic< OCT imaging of a live mouse using wavefront shaping (WS) to enhance the penetration depth. A digital micromirror device was used in a spectral-domain OCT system for complex WS of an incident beam which resulted in the optimal delivery of light energy into deep tissue. <italic<Ex vivo</italic< imaging of chicken breasts and mouse ear tissues showed enhancements in the strength of the image signals and the penetration depth, and <italic<in vivo</italic< imaging of the tail of a live mouse provided a multilayered structure inside the tissue.

Paper Details

Date Published: 19 February 2016
PDF: 4 pages
J. Biomed. Opt. 21(10) 101406 doi: 10.1117/1.JBO.21.10.101406
Published in: Journal of Biomedical Optics Volume 21, Issue 10
Show Author Affiliations
Hyeonseung Yu, KAIST (Korea, Republic of)
KI for optical Science and Technology (Korea, Republic of)
Peter Lee, KI for optical Science and Technology (Korea, Republic of)
KAIST (Korea, Republic of)
KyeoReh Lee, KAIST (Republic of Korea)
KI for Optical Science and Technology (Republic of Korea)
Jaeduck Jang, Samsung Advanced Institute of Technology (Republic of Korea)
Jaeguyn Lim, SAMSUNG Electronics Co., Ltd. (Republic of Korea)
Wooyoung Jang, SAMSUNG Electronics Co., Ltd. (Republic of Korea)
Yong Jeong, KI for optical Science and Technology (Korea, Republic of)
KAIST (Korea, Republic of)
YongKeun Park, KAIST (Republic of Korea)
KI for Optical Science and Technology (Republic of Korea)
Tomocube, Inc. (Republic of Korea)


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