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Journal of Biomedical Optics • Open Access

Optical mammography: bilateral breast symmetry in hemoglobin saturation maps
Author(s): Pamela G. Anderson; Angelo Sassaroli; Jana Marie Kainerstorfer; Nishanth Krishnamurthy; Sirishma Kalli; Shital S. Makim; Roger A. Graham; Sergio Fantini

Paper Abstract

We present a study of the bilateral symmetry of human breast hemoglobin saturation maps measured with a broadband optical mammography instrument. We have imaged 21 patients with unilateral breast cancer, 32 patients with unilateral benign lesions, and 27 healthy patients. An image registration process was applied to the bilateral hemoglobin saturation (SO2) images by assigning each pixel to the low, middle, or high range of SO2 values, where the thresholds for the categories were the 15th and 85th percentiles of the individual saturation range. The Dice coefficient, which is a measure of similarity, was calculated for each patient’s pair of right and left breast SO2 images. The invasive cancer patients were found to have an average Dice coefficient value of 0.55±0.07, which was significantly lower than the benign and healthy groups (0.61±0.11 and 0.62±0.12, respectively). Although differences were seen in a group analysis, the healthy patient Dice coefficients spanned a wide range, limiting the diagnostic capabilities of this SO2 symmetry analysis on an individual basis. Our results suggest that for assessing the SO2 contrast of breast lesions, it may be better to select a reference tissue in the ipsilateral rather than the contralateral breast.

Paper Details

Date Published: 5 February 2016
PDF: 12 pages
J. Biomed. Opt. 21(10) 101403 doi: 10.1117/1.JBO.21.10.101403
Published in: Journal of Biomedical Optics Volume 21, Issue 10
Show Author Affiliations
Pamela G. Anderson, Tufts Univ. (United States)
Angelo Sassaroli, Tufts Univ. (United States)
Jana Marie Kainerstorfer, Tufts Univ. (United States)
Nishanth Krishnamurthy, Tufts Univ. (United States)
Sirishma Kalli, Tufts Medical Ctr. (United States)
Shital S. Makim, Tufts Medical Ctr. (United States)
Roger A. Graham, Tufts Medical Ctr. (United States)
Sergio Fantini, Tufts Univ. (United States)


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