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Journal of Biomedical Optics • Open Access

Characterizing optical properties and spatial heterogeneity of human ovarian tissue using spatial frequency domain imaging
Author(s): Sreyankar Nandy; Atahar Mostafa; Patrick D. Kumavor; Melinda Sanders; Molly Brewer; Quing Zhu

Paper Abstract

A spatial frequency domain imaging (SFDI) system was developed for characterizing <italic<ex vivo</italic< human ovarian tissue using wide-field absorption and scattering properties and their spatial heterogeneities. Based on the observed differences between absorption and scattering images of different ovarian tissue groups, six parameters were quantitatively extracted. These are the mean absorption and scattering, spatial heterogeneities of both absorption and scattering maps measured by a standard deviation, and a fitting error of a Gaussian model fitted to normalized mean Radon transform of the absorption and scattering maps. A logistic regression model was used for classification of malignant and normal ovarian tissues. A sensitivity of 95%, specificity of 100%, and area under the curve of 0.98 were obtained using six parameters extracted from the SFDI images. The preliminary results demonstrate the diagnostic potential of the SFDI method for quantitative characterization of wide-field optical properties and the spatial distribution heterogeneity of human ovarian tissue. SFDI could be an extremely robust and valuable tool for evaluation of the ovary and detection of neoplastic changes of ovarian cancer.

Paper Details

Date Published: 28 January 2016
PDF: 8 pages
J. Biomed. Opt. 21(10) 101402 doi: 10.1117/1.JBO.21.10.101402
Published in: Journal of Biomedical Optics Volume 21, Issue 10
Show Author Affiliations
Sreyankar Nandy, Univ. of Connecticut (United States)
Atahar Mostafa, Univ. of Connecticut (United States)
Patrick D. Kumavor, Univ. of Connecticut (United States)
Melinda Sanders, Univ. of Connecticut Health Ctr. (United States)
Molly Brewer, Univ. of Connecticut Health Ctr. (United States)
Quing Zhu, Univ. of Connecticut (United States)


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