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Journal of Biomedical Optics

Photodynamic antimicrobial chemotherapy using zinc phthalocyanine derivatives in treatment of bacterial skin infection
Author(s): Zhuo Chen; Yaxin Zhang; Dong Wang; Linsen Li; Shanyong Zhou; Joy H. Huang; Jincan Chen; Ping Hu; Mingdong Huang
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Paper Abstract

Photodynamic antimicrobial chemotherapy (PACT) is an effective method for killing bacterial cells in view of the increasing problem of multiantibiotic resistance. We herein reported the PACT effect on bacteria involved in skin infections using a zinc phthalocyanine derivative, pentalysine β-carbonylphthalocyanine zinc (ZnPc-(Lys)5). Compared with its anionic ZnPc counterpart, ZnPc-(Lys)5 showed an enhanced antibacterial efficacy in vitro and in an animal model of localized infection. Meanwhile, ZnPc-(Lys)5 was observed to significantly reduce the wound skin blood flow during wound healing, indicating an anti-inflammation activity. This study provides new insight on the mechanisms of PACT in bacterial skin infection.

Paper Details

Date Published: 7 January 2016
PDF: 7 pages
J. Biomed. Opt. 21(1) 018001 doi: 10.1117/1.JBO.21.1.018001
Published in: Journal of Biomedical Optics Volume 21, Issue 1
Show Author Affiliations
Zhuo Chen, Fujian Institute of Research on the Structure of Matter (China)
Graduate Univ. of Chinese Academy of Sciences (China)
Yaxin Zhang, Fujian Institute of Research on the Structure of Matter (China)
Graduate Univ. of Chinese Academy of Sciences (China)
Fujian Normal Univ. (China)
Dong Wang, Fujian Institute of Research on the Structure of Matter (China)
Graduate Univ. of Chinese Academy of Sciences (China)
Fujian Normal Univ. (China)
Linsen Li, Shenyang Medical College (China)
Shanyong Zhou, Fujian Institute of Research on the Structure of Matter (China)
Joy H. Huang, Fujian Institute of Research on the Structure of Matter (China)
Jincan Chen, Fujian Institute of Research on the Structure of Matter (China)
Ping Hu, Fujian Institute of Research on the Structure of Matter (China)
Mingdong Huang, Fujian Institute of Research on the Structure of Matter (China)
Graduate Univ. of Chinese Academy of Sciences (China)


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