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Journal of Biomedical Optics

Experimental validation of a high-resolution diffuse optical imaging modality: photomagnetic imaging
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Paper Abstract

We present experimental results that validate our imaging technique termed photomagnetic imaging (PMI). PMI illuminates the medium under investigation with a near-infrared light and measures the induced temperature increase using magnetic resonance imaging. A multiphysics solver combining light and heat propagation is used to model spatiotemporal distribution of temperature increase. Furthermore, a dedicated PMI reconstruction algorithm has been developed to reveal high-resolution optical absorption maps from temperature measurements. Being able to perform measurements at any point within the medium, PMI overcomes the limitations of conventional diffuse optical imaging. We present experimental results obtained on agarose phantoms mimicking biological tissue with inclusions having either different sizes or absorption contrasts, located at various depths. The reconstructed images show that PMI can successfully resolve these inclusions with high resolution and recover their absorption coefficient with high-quantitative accuracy. Even a 1-mm inclusion located 6-mm deep is recovered successfully and its absorption coefficient is underestimated by only 32%. The improved PMI system presented here successfully operates under the maximum skin exposure limits defined by the American National Standards Institute, which opens up the exciting possibility of its future clinical use for diagnostic purposes.

Paper Details

Date Published: 20 January 2016
PDF: 9 pages
J. Biomed. Opt. 21(1) 016009 doi: 10.1117/1.JBO.21.1.016009
Published in: Journal of Biomedical Optics Volume 21, Issue 1
Show Author Affiliations
Farouk Nouizi, John Tu & Thomas Yuen Ctr. for Functional Onco-Imaging (United States)
Alex T. Luk, John Tu & Thomas Yuen Ctr. for Functional Onco-Imaging (United States)
Dave Thayer, John Tu & Thomas Yuen Ctr. for Functional Onco-Imaging (United States)
Washington Univ. in St. Louis (United States)
Yuting Lin, John Tu & Thomas Yuen Ctr. for Functional Onco-Imaging (United States)
Massachusetts General Hospital (United States)
Harvard Medical School (United States)
Seunghoon Ha, John Tu & Thomas Yuen Ctr. for Functional Onco-Imaging (United States)
Philips Healthcare (United States)
Gultekin Gulsen, John Tu & Thomas Yuen Ctr. for Functional Onco-Imaging (United States)


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