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Journal of Biomedical Optics

Combined reflectance confocal microscopy-optical coherence tomography for delineation of basal cell carcinoma margins: an <italic<ex vivo</italic< study
Author(s): Nicusor V. Iftimia; Gary Peterson; Ernest W. Chang; Gopi N. Maguluri; William J. Fox; Milind Rajadhyaksha
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Paper Abstract

We present a combined reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) approach, integrated within a single optical layout, for diagnosis of basal cell carcinomas (BCCs) and delineation of margins. While RCM imaging detects BCC presence (diagnoses) and its lateral spreading (margins) with measured resolution of ∼1  μm, OCT imaging delineates BCC depth spreading (margins) with resolution of ∼7  μm. When delineating margins in 20 specimens of superficial and nodular BCCs, depth could be reliably determined down to ∼600  μm, and agreement with histology was within about ±50  μm.

Paper Details

Date Published: 18 January 2016
PDF: 7 pages
J. Biomed. Opt. 21(1) 016006 doi: 10.1117/1.JBO.21.1.016006
Published in: Journal of Biomedical Optics Volume 21, Issue 1
Show Author Affiliations
Nicusor V. Iftimia, Physical Sciences Inc. (United States)
Gary Peterson, Memorial Sloan-Kettering Cancer Ctr. (United States)
Ernest W. Chang, Physical Sciences Inc. (United States)
Gopi N. Maguluri, Physical Sciences Inc. (United States)
William J. Fox, Caliber Imaging & Diagnostics, Inc. (United States)
Milind Rajadhyaksha, Memorial Sloan-Kettering Cancer Ctr. (United States)

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