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Journal of Biomedical Optics

<italic<In vivo</italic< use of hyperspectral imaging to develop a noncontact endoscopic diagnosis support system for malignant colorectal tumors
Author(s): Zhimin Han; Aoyu Zhang; Xiguang Wang; Zongxiao Sun; May D. Wang; Tianyu Xie
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Paper Abstract

The early detection and diagnosis of malignant colorectal tumors enables the initiation of early-stage therapy and can significantly increase the survival rate and post-treatment quality of life among cancer patients. Hyperspectral imaging (HSI) is recognized as a powerful tool for noninvasive cancer detection. In the gastrointestinal field, most of the studies on HSI have involved <italic<ex vivo</italic< biopsies or resected tissues. In the present study, we aimed to assess the difference in the <italic<in vivo</italic< spectral reflectance of malignant colorectal tumors and normal mucosa. A total of 21 colorectal tumors or adenomatous polyps from 12 patients at Shanghai Zhongshan Hospital were examined using a flexible hyperspectral (HS) colonoscopy system that can obtain <italic<in vivo</italic< HS images of the colorectal mucosa. We determined the optimal wavelengths for differentiating tumors from normal tissue based on these recorded images. The application of the determined wavelengths in spectral imaging in clinical trials indicated that such a clinical support system comprising a flexible HS colonoscopy unit and band selection unit is useful for outlining the tumor region and enhancing the display of the mucosa microvascular pattern <italic<in vivo</italic<.

Paper Details

Date Published: 6 January 2016
PDF: 8 pages
J. Biomed. Opt. 21(1) 016001 doi: 10.1117/1.JBO.21.1.016001
Published in: Journal of Biomedical Optics Volume 21, Issue 1
Show Author Affiliations
Zhimin Han, Peking Univ. (China)
Georgia Institute of Technology (United States)
Emory Univ. (United States)
Aoyu Zhang, Peking Univ. (China)
Xiguang Wang, Peking Univ. (China)
Zongxiao Sun, Peking Univ. (China)
May D. Wang, Georgia Institute of Technology (United States)
Emory Univ. (United States)
Tianyu Xie, Peking Univ. (China)


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