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Journal of Biomedical Optics

Terahertz spectroscopy of brain tissue from a mouse model of Alzheimer’s disease
Author(s): Lingyan Shi; Pavel Shumyatsky; Adrián Rodríguez-Contreras; Robert R. Alfano
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Paper Abstract

The terahertz (THz) absorption and index of refraction of brain tissues from a mouse model of Alzheimer’s disease (AD) and a control wild-type (normal) mouse were compared using THz time-domain spectroscopy (THz-TDS). Three dominating absorption peaks associated to torsional–vibrational modes were observed in AD tissue, at about 1.44, 1.8, and 2.114 THz, closer to the peaks of free tryptophan molecules than in normal tissue. A possible reason is that there is more free tryptophan in AD brain tissue, while in normal brain tissue more tryptophan is attached to other molecules. Our study suggests that THz-absorption modes may be used as an AD biomarker fingerprint in brain, and that THz-TDS is a promising technique for early diagnosis of AD.

Paper Details

Date Published: 27 January 2016
PDF: 5 pages
J. Biomed. Opt. 21(1) 015014 doi: 10.1117/1.JBO.21.1.015014
Published in: Journal of Biomedical Optics Volume 21, Issue 1
Show Author Affiliations
Lingyan Shi, The City College of New York (United States)
Pavel Shumyatsky, The City College of New York (United States)
Adrián Rodríguez-Contreras, The City College of New York (United States)
Robert R. Alfano, The City College of New York (United States)


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