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Journal of Biomedical Optics

Corneal thermal damage threshold dependence on the exposure duration for near-infrared laser radiation at 1319 nm
Author(s): Jiarui Wang; Luguang Jiao; Hongxia Chen; Zaifu Yang; Xiangjun Hu
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Paper Abstract

The corneal damage effects induced by 1319-nm transitional near-infrared laser have been investigated for years. However, the damage threshold dependence on exposure duration has not been revealed. The in vivo corneal damage thresholds (ED50s) were determined in New Zealand rabbits for 1319-nm laser radiation for exposure durations from 75 ms to 10 s. An additional corneal ED50 was determined at 1338 nm for a 5-ms exposure. The incident corneal irradiance diameter was fixed at 2 mm for all exposure conditions to avoid the influence of spot size on threshold. The ED50s given in terms of the corneal radiant exposure for exposure durations of 5 ms, 75 ms, 0.35 s, 2 s, and 10 s were 39.4, 51.5, 87.2, 156.3, and 311.1  J/cm2, respectively. The 39.4  J/cm2 was derived from the ED50 for 1338 nm (27.0  J/cm2). The ED50s for exposure durations of 75 ms to 10 s were correlated by a power law equation, ED50=128.9t0.36 in J/cm2, where t was the input in the unit of second, with correlation coefficient (R) of 0.997. Enough safe margins existed between the ED50s and the maximum permitted exposures from current laser safety standard.

Paper Details

Date Published: 25 January 2016
PDF: 6 pages
J. Biomed. Opt. 21(1) 015011 doi: 10.1117/1.JBO.21.1.015011
Published in: Journal of Biomedical Optics Volume 21, Issue 1
Show Author Affiliations
Jiarui Wang, Beijing Institute of Radiation Medicine (China)
Luguang Jiao, Beijing Institute of Radiation Medicine (China)
Hongxia Chen, Chinese PLA General Hospital (China)
Zaifu Yang, Beijing Institute of Radiation Medicine (China)
Xiangjun Hu, Beijing Institute of Radiation Medicine (China)


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