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Journal of Biomedical Optics

Assessment of asthmatic inflammation using hybrid fluorescence molecular tomography–x-ray computed tomography
Author(s): Xiaopeng Ma; Jaya Prakash; Francesca Ruscitti; Sarah Glasl; Fabio Franco Stellari; Gino Villetti; Vasilis Ntziachristos
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Paper Abstract

Nuclear imaging plays a critical role in asthma research but is limited in its readings of biology due to the short-lived signals of radio-isotopes. We employed hybrid fluorescence molecular tomography (FMT) and x-ray computed tomography (XCT) for the assessment of asthmatic inflammation based on resolving cathepsin activity and matrix metalloproteinase activity in dust mite, ragweed, and <italic<Aspergillus</italic< species-challenged mice. The reconstructed multimodal fluorescence distribution showed good correspondence with <italic<ex vivo</italic< cryosection images and histological images, confirming FMT-XCT as an interesting alternative for asthma research.

Paper Details

Date Published: 21 January 2016
PDF: 9 pages
J. Biomed. Opt. 21(1) 015009 doi: 10.1117/1.JBO.21.1.015009
Published in: Journal of Biomedical Optics Volume 21, Issue 1
Show Author Affiliations
Xiaopeng Ma, Helmholtz Zentrum München GmbH (Germany)
Technische Univ. München (Germany)
Jaya Prakash, Helmholtz Zentrum München GmbH (Germany)
Technische Univ. München (Germany)
Francesca Ruscitti, Univ. degli Studi di Parma (Italy)
Sarah Glasl, Helmholtz Zentrum München GmbH (Germany)
Technische Univ. München (Germany)
Fabio Franco Stellari, Chiesi Farmaceutici S.p.A. (Italy)
Gino Villetti, Chiesi Farmaceutici S.p.A. (Italy)
Vasilis Ntziachristos, Helmholtz Zentrum München GmbH (Germany)
Technische Univ. München (Germany)

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