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Journal of Biomedical Optics

Intraoperative laser speckle contrast imaging improves the stability of rodent middle cerebral artery occlusion model
Author(s): Lu Yuan; Yao Li; Hangdao Li; Hongyang Lu; Shanbao Tong
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Paper Abstract

Rodent middle cerebral artery occlusion (MCAO) model is commonly used in stroke research. Creating a stable infarct volume has always been challenging for technicians due to the variances of animal anatomy and surgical operations. The depth of filament suture advancement strongly influences the infarct volume as well. We investigated the cerebral blood flow (CBF) changes in the affected cortex using laser speckle contrast imaging when advancing suture during MCAO surgery. The relative CBF drop area (CBF50, i.e., the percentage area with CBF less than 50% of the baseline) showed an increase from 20.9% to 69.1% when the insertion depth increased from 1.6 to 1.8 cm. Using the real-time CBF50 marker to guide suture insertion during the surgery, our animal experiments showed that intraoperative CBF-guided surgery could significantly improve the stability of MCAO with a more consistent infarct volume and less mortality.

Paper Details

Date Published: 11 September 2015
PDF: 5 pages
J. Biomed. Opt. 20(9) 096012 doi: 10.1117/1.JBO.20.9.096012
Published in: Journal of Biomedical Optics Volume 20, Issue 9
Show Author Affiliations
Lu Yuan, Shanghai Jiao Tong Univ. (China)
Yao Li, Shanghai Jiao Tong Univ. (China)
Hangdao Li, Shanghai Jiao Tong Univ. (China)
Hongyang Lu, Shanghai Jiao Tong Univ. (China)
Shanbao Tong, Shanghai Jiao Tong Univ. (China)

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