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Journal of Biomedical Optics • Open Access

Monitoring the progression from intraductal carcinoma to invasive ductal carcinoma based on multiphoton microscopy
Author(s): Yan Wu; Fangmeng Fu; Yuane Lian; Yuting Nie; Shuangmu Zhuo; Chuan Wang; Jianxin Chen

Paper Abstract

Intraductal carcinoma is a precancerous lesion of the breast and the immediate precursor of invasive ductal carcinoma. Multiphoton microscopy (MPM) was used to monitor the progression from intraductal carcinoma to invasive ductal carcinoma, which can improve early detection of precursor lesions and halt progression to invasive neoplastic disease. It was found that MPM has the capability to reveal the qualitative changes in features of cells, structure of basement membranes, and architecture of collagens during the development from intraductal carcinoma to invasive ductal carcinoma, as well as the quantitative alterations in nuclear area, circle length of basement membrane, and collagen density. Combined with intra-fiberoptic ductoscopy or transdermal biopsy needle, MPM has the potential to provide immediate histological diagnosis of tumor progression in the field of breast carcinoma.

Paper Details

Date Published: 10 September 2015
PDF: 9 pages
J. Biomed. Opt. 20(9) 096007 doi: 10.1117/1.JBO.20.9.096007
Published in: Journal of Biomedical Optics Volume 20, Issue 9
Show Author Affiliations
Yan Wu, Fujian Normal Univ. (China)
Jimei University (China)
Fangmeng Fu, Fujian Medical Univ. (China)
Yuane Lian, Fujian Medical Univ. (China)
Yuting Nie, Fujian Normal Univ. (China)
Shuangmu Zhuo, Fujian Normal Univ. (China)
Chuan Wang, Fujian Medical Univ. (China)
Jianxin Chen, Fujian Normal Univ. (China)

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