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Journal of Biomedical Optics • Open Access

Trends in nanosecond melanosome microcavitation up to 1540 nm

Paper Abstract

Thresholds for microcavitation of bovine and porcine melanosomes were previously reported, using single nanosecond (ns) laser pulses in the visible (532 nm) and the near-infrared (NIR) from 1000 to 1319 nm. Here, we report average radiant exposure thresholds for bovine melanosome microcavitation at additional NIR wavelengths up to 1540 nm, which range from ∼0.159  J/cm2 at 800 nm to 4.5  J/cm2 at 1540 nm. Melanosome absorption coefficients were also estimated, and decreased with increasing wavelength. These values were compared to retinal pigment epithelium coefficients, and to water absorption, over the same wavelength range. Corneal total intraocular energy retinal damage threshold values were estimated and compared to the previous (2007) and recently changed (2014) maximum permissible exposure (MPE) safe levels. Results provide additional data that support the recent changes to the MPE levels, as well as the first microcavitation data at 1540 nm, a wavelength for which melanosome microcavitation may be an ns-pulse skin damage mechanism.

Paper Details

Date Published: 21 September 2015
PDF: 6 pages
J. Biomed. Opt. 20(9) 095011 doi: 10.1117/1.JBO.20.9.095011
Published in: Journal of Biomedical Optics Volume 20, Issue 9
Show Author Affiliations
Morgan S. Schmidt, Air Force Research Lab. (United States)
Human Effectiveness Directorate (United States)
Paul K. Kennedy, Air Force Research Lab. (United States)
Human Effectiveness Directorate (United States)
Gary D. Noojin, Engility Corp. (United States)
Rebecca L. Vincelette, Engility Corp. (United States)
Robert J. Thomas, Air Force Research Lab. (United States)
Human Effectiveness Directorate (United States)
Benjamin A. Rockwell, Air Force Research Lab. (United States)
Human Effectiveness Directorate (United States)


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