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Journal of Biomedical Optics • Open Access

Terahertz spectroscopy of oligonucleotides in aqueous solutions
Author(s): Mingjie Tang; Qing Huang; Dongshan Wei; Guozhong Zhao; Tianying Chang; Kuan Kou; Min Wang; Chunlei Du; Wei-ling Fu; Hong-Liang Cui

Paper Abstract

A terahertz (THz) spectroscopic study is carried out to analyze DNA mutations in a label-free manner. Three newly designed liquid sample cells are considered and the best is selected as the sample carrier for THz transmission spectroscopic analyses. Discrimination based on spectral signatures of single-base mutations on single-stranded 20 nt oligonucleotides has been shown possible experimentally. The results clearly attest the ability of this promising approach for label-free analyses of single-base mutations of DNA molecules. This study has demonstrated that the THz spectroscopic technology can be considered as a potential diagnostic tool for investigating molecular reactions, such as DNA mutations.

Paper Details

Date Published: 21 September 2015
PDF: 5 pages
J. Biomed. Opt. 20(9) 095009 doi: 10.1117/1.JBO.20.9.095009
Published in: Journal of Biomedical Optics Volume 20, Issue 9
Show Author Affiliations
Mingjie Tang, Chinese Academy of Sciences (China)
Qing Huang, Third Military Medical Univ. (China)
Dongshan Wei, Chongqing Institute of Green and Intelligent Technology (China)
Guozhong Zhao, Capital Normal Univ. (China)
Tianying Chang, Chinese Academy of Sciences (China)
Jilin Univ. (China)
Kuan Kou, Capital Normal Univ. (China)
Min Wang, Jilin Univ. (China)
Chunlei Du, Chongqing Institute of Green and Intelligent Technology (China)
Wei-ling Fu, Third Military Medical Univ. (China)
Hong-Liang Cui, Chinese Academy of Sciences (China)
Jilin Univ. (China)

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