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Journal of Biomedical Optics • Open Access

Intrinsic optical signal imaging of retinal physiology: a review

Paper Abstract

Intrinsic optical signal (IOS) imaging promises to be a noninvasive method for high-resolution examination of retinal physiology, which can advance the study and diagnosis of eye diseases. While specialized optical instruments are desirable for functional IOS imaging of retinal physiology, in depth understanding of multiple IOS sources in the complex retinal neural network is essential for optimizing instrument designs. We provide a brief overview of IOS studies and relationships in rod outer segment suspensions, isolated retinas, and intact eyes. Recent developments of line-scan confocal and functional optical coherence tomography (OCT) instruments have allowed in vivo IOS mapping of photoreceptor physiology. Further improvements of the line-scan confocal and functional OCT systems may provide a feasible solution to pursue functional IOS mapping of human photoreceptors. Some interesting IOSs have already been detected in inner retinal layers, but better development of the IOS instruments and software algorithms is required to achieve optimal physiological assessment of inner retinal neurons.

Paper Details

Date Published: 25 September 2015
PDF: 20 pages
J. Biomed. Opt. 20(9) 090901 doi: 10.1117/1.JBO.20.9.090901
Published in: Journal of Biomedical Optics Volume 20, Issue 9
Show Author Affiliations
Xincheng Yao, Univ. of Illinois at Chicago (United States)
Benquan Wang, Univ. of Illinois at Chicago (United States)

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