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Journal of Biomedical Optics

In vivo photoacoustic flowmetry at depths of the diffusive regime based on saline injection
Author(s): Yong Zhou; Joemini Poudel; Guo Li; Lihong V. Wang
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Paper Abstract

We propose a saline injection-based method to quantify blood flow velocity in vivo with acoustic-resolution photoacoustic tomography. By monitoring the saline–blood interface propagating in the blood vessel, the flow velocity can be resolved. We first demonstrated our method in phantom experiments, where a root mean square error of prediction of 0.29  mm/s was achieved. By injecting saline into a mouse tail vein covered with 1 mm chicken tissue, we showed that the flow velocity in the tail vein could be measured at depths, which is especially pertinent to monitoring blood flow velocity in patients undergoing intravenous infusion.

Paper Details

Date Published: 12 August 2015
PDF: 4 pages
J. Biomed. Opt. 20(8) 087001 doi: 10.1117/1.JBO.20.8.087001
Published in: Journal of Biomedical Optics Volume 20, Issue 8
Show Author Affiliations
Yong Zhou, Washington Univ. in St. Louis (United States)
Joemini Poudel, Washington Univ. in St. Louis (United States)
Guo Li, Washington Univ. in St. Louis (United States)
Lihong V. Wang, Washington Univ. in St. Louis (United States)

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