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Journal of Biomedical Optics

Multispectral hybrid Cerenkov luminescence tomography based on the finite element SPn method
Author(s): Haixiao Liu; Xin Yang; Tianming Song; Chengpeng Bao; Liangliang Shi; Zhenhua Hu; Kun Wang; Jie Tian
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Paper Abstract

Cerenkov luminescence tomography (CLT) is a promising tool that enables three-dimensional noninvasive in vivo detection of radiopharmaceuticals. Conventionally, multispectral information and diffusion theory were introduced to achieve whole-body tomographic reconstruction. However, the diffusion theory inevitably causes systematic error in blue bands of the electromagnetic spectrum due to high-tissue absorption, and CL has a blue-weighted broad spectrum. Therefore, it is challenging to improve the accuracy of CLT. The performance of the n-order simplified spherical harmonics approximation (SPn) in different spectra is evaluated, and a multispectral hybrid CLT based on the combination of different SPn models is proposed to handle the Cerenkov photon transport problem in complex media. The in vivo xenograft experiment shows that this approach can effectively improve the quality and accuracy of the reconstructed light source. We believe that the new reconstruction method will advance the development of CLT for more in vivo imaging applications.

Paper Details

Date Published: 13 August 2015
PDF: 8 pages
J. Biomed. Opt. 20(8) 086007 doi: 10.1117/1.JBO.20.8.086007
Published in: Journal of Biomedical Optics Volume 20, Issue 8
Show Author Affiliations
Haixiao Liu, Institute of Automation (China)
Beijing Key Laboratory of Molecular Imaging (China)
Xin Yang, Institute of Automation (China)
Tianming Song, Institute of Automation (China)
Chengpeng Bao, Institute of Automation (China)
Liangliang Shi, Institute of Automation (China)
Beijing Key Laboratory of Molecular Imaging (China)
Zhenhua Hu, Institute of Automation (China)
Beijing Key Laboratory of Molecular Imaging (China)
Kun Wang, Institute of Automation (China)
Beijing Key Laboratory of Molecular Imaging (China)
Jie Tian, Institute of Automation (China)
Beijing Key Laboratory of Molecular Imaging (China)


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