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Journal of Biomedical Optics

Performance characteristics of an interventional multispectral photoacoustic imaging system for guiding minimally invasive procedures
Author(s): Wenfeng Xia; Daniil I. Nikitichev; Jean Martial Mari; Simeon J. West; Rosalind Pratt; Anna L. David; Sébastien Ourselin; Paul C. Beard; Adrien E. Desjardins
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Paper Abstract

Precise device guidance is important for interventional procedures in many different clinical fields including fetal medicine, regional anesthesia, interventional pain management, and interventional oncology. While ultrasound is widely used in clinical practice for real-time guidance, the image contrast that it provides can be insufficient for visualizing tissue structures such as blood vessels, nerves, and tumors. This study was centered on the development of a photoacoustic imaging system for interventional procedures that delivered excitation light in the ranges of 750 to 900 nm and 1150 to 1300 nm, with an optical fiber positioned in a needle cannula. Coregistered B-mode ultrasound images were obtained. The system, which was based on a commercial ultrasound imaging scanner, has an axial resolution in the vicinity of 100 μm and a submillimeter, depth-dependent lateral resolution. Using a tissue phantom and 800 nm excitation light, a simulated blood vessel could be visualized at a maximum distance of 15 mm from the needle tip. Spectroscopic contrast for hemoglobin and lipids was observed with ex vivo tissue samples, with photoacoustic signal maxima consistent with the respective optical absorption spectra. The potential for further optimization of the system is discussed.

Paper Details

Date Published: 11 August 2015
PDF: 10 pages
J. Biomed. Opt. 20(8) 086005 doi: 10.1117/1.JBO.20.8.086005
Published in: Journal of Biomedical Optics Volume 20, Issue 8
Show Author Affiliations
Wenfeng Xia, Univ. College London (United Kingdom)
Daniil I. Nikitichev, Univ. College London (United Kingdom)
Jean Martial Mari, Univ. College London (United Kingdom)
Simeon J. West, Univ. College Hospital (United Kingdom)
Rosalind Pratt, Univ. College London (United Kingdom)
Anna L. David, Univ. College Hospital (United Kingdom)
Sébastien Ourselin, Univ. College London (United Kingdom)
Paul C. Beard, Univ. College London (United Kingdom)
Adrien E. Desjardins, Univ. College London (United Kingdom)

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