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Journal of Biomedical Optics

Noncontact diffuse correlation tomography of human breast tumor
Author(s): Lian He; Yu Lin; Chong Huang; Daniel Irwin; Margaret M. Szabunio; Guoqiang Yu
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Paper Abstract

Our first step to adapt our recently developed noncontact diffuse correlation tomography (ncDCT) system for three-dimensional (3-D) imaging of blood flow distribution in human breast tumors is reported. A commercial 3-D camera was used to obtain breast surface geometry, which was then converted to a solid volume mesh. An ncDCT probe scanned over a region of interest on the mesh surface and the measured boundary data were combined with a finite element framework for 3-D image reconstruction of blood flow distribution. This technique was tested in computer simulations and <italic<in vivo</italic< human breasts with low-grade carcinoma. Results from computer simulations suggest that relatively high accuracy can be achieved when the entire tumor is within the sensitive region of diffuse light. Image reconstruction with <italic<a priori</italic< knowledge of the tumor volume and location can significantly improve the accuracy in recovery of tumor blood flow contrasts. <italic<In vivo</italic< imaging results from two breast carcinomas show higher average blood flow contrasts (5.9- and 10.9-fold) in the tumor regions compared to the surrounding tissues, which are comparable with previous findings using diffuse correlation spectroscopy. The ncDCT system has the potential to image blood flow distributions in soft and vulnerable tissues without distorting tissue hemodynamics.

Paper Details

Date Published: 11 August 2015
PDF: 11 pages
J. Biomed. Opt. 20(8) 086003 doi: 10.1117/1.JBO.20.8.086003
Published in: Journal of Biomedical Optics Volume 20, Issue 8
Show Author Affiliations
Lian He, Univ. of Kentucky (United States)
Yu Lin, Univ. of Kentucky (United States)
Chong Huang, Univ. of Kentucky (United States)
Daniel Irwin, Univ. of Kentucky (United States)
Margaret M. Szabunio, Univ. of Kentucky (United States)
Guoqiang Yu, Univ. of Kentucky (United States)

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