Share Email Print

Journal of Biomedical Optics • Open Access

Characterizing breast lesions through robust multimodal data fusion using independent diffuse optical and x-ray breast imaging
Author(s): Bin Deng; Maxim Fradkin; Jean-Michel Rouet; Mats Lundqvist; Richard H. Moore; Daniel B. Kopans; Qianqian Fang; David A. Boas

Paper Abstract

To enable tissue function-based tumor diagnosis over the large number of existing digital mammography systems worldwide, we propose a cost-effective and robust approach to incorporate tomographic optical tissue characterization with separately acquired digital mammograms. Using a flexible contour-based registration algorithm, we were able to incorporate an independently measured two-dimensional x-ray mammogram as structural priors in a joint optical/x-ray image reconstruction, resulting in improved spatial details in the optical images and robust optical property estimation. We validated this approach with a retrospective clinical study of 67 patients, including 30 malignant and 37 benign cases, and demonstrated that the proposed approach can help to distinguish malignant from solid benign lesions and fibroglandular tissues, with a performance comparable to the approach using spatially coregistered optical/x-ray measurements.

Paper Details

Date Published: 11 August 2015
PDF: 4 pages
J. Biomed. Opt. 20(8) 080502 doi: 10.1117/1.JBO.20.8.080502
Published in: Journal of Biomedical Optics Volume 20, Issue 8
Show Author Affiliations
Bin Deng, Massachusetts General Hospital (United States)
Maxim Fradkin, Philips Research Medisys (France)
Jean-Michel Rouet, Philips Research Medisys (France)
Mats Lundqvist, Philips Healthcare (Sweden)
Richard H. Moore, Massachusetts General Hospital (United States)
Daniel B. Kopans, Massachusetts General Hospital (United States)
Qianqian Fang, Massachusetts General Hospital (United States)
David A. Boas, Athinoula A. Martinos Ctr. for Biomedical Imaging (United States)

© SPIE. Terms of Use
Back to Top