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Journal of Biomedical Optics

Contrast improvement of continuous wave diffuse optical tomography reconstruction by hybrid approach using least square and genetic algorithm
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Paper Abstract

Reconstruction of the absorption coefficient of tissue with good contrast is of key importance in functional diffuse optical imaging. A hybrid approach using model-based iterative image reconstruction and a genetic algorithm is proposed to enhance the contrast of the reconstructed image. The proposed method yields an observed contrast of 98.4%, mean square error of 0.638×10−3, and object centroid error of (0.001 to 0.22) mm. Experimental validation of the proposed method has also been provided with tissue-like phantoms which shows a significant improvement in image quality and thus establishes the potential of the method for functional diffuse optical tomography reconstruction with continuous wave setup. A case study of finger joint imaging is illustrated as well to show the prospect of the proposed method in clinical diagnosis. The method can also be applied to the concentration measurement of a region of interest in a turbid medium.

Paper Details

Date Published: 29 July 2015
PDF: 10 pages
J. Biomed. Opt. 20(7) 075009 doi: 10.1117/1.JBO.20.7.075009
Published in: Journal of Biomedical Optics Volume 20, Issue 7
Show Author Affiliations
Rusha Patra, Indian Institute of Technology Kharagpur (India)
Pranab K. Dutta, Indian Institute of Technology Kharagpur (India)

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