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Journal of Biomedical Optics • Open Access

Wide-field imaging of retinal vasculature using optical coherence tomography-based microangiography provided by motion tracking
Author(s): Qinqin Zhang; Yanping Huang; Thomas Zhang; Sophie Kubach; Lin An; Michal Laron; Utkarsh Sharma; Ruikang K. Wang

Paper Abstract

Optical coherence tomography (OCT)-based optical microangiography (OMAG) is a high-resolution, noninvasive imaging technique capable of providing three-dimensional in vivo blood flow visualization within microcirculatory tissue beds in the eye. Although the technique has demonstrated early clinical utility by imaging diseased eyes, its limited field of view (FOV) and the sensitivity to eye motion remain the two biggest challenges for the widespread clinical use of the technology. Here, we report the results of retinal OMAG imaging obtained from a Zeiss Cirrus 5000 spectral domain OCT system with motion tracking capability achieved by a line scan ophthalmoscope (LSO). The tracking LSO is able to guide the OCT scanning, which minimizes the effect of eye motion in the final results. We show that the tracking can effectively correct the motion artifacts and remove the discontinuities and distortions of vascular appearance due to microsaccade, leading to almost motion-free OMAG angiograms with good repeatability and reliability. Due to the robustness of the tracking LSO, we also show the montage scan protocol to provide unprecedented wide field retinal OMAG angiograms. We experimentally demonstrate a 12×16  mm2 retinal OMAG angiogram acquired from a volunteer, which is the widest FOV retinal vasculature imaging up to now in the community.

Paper Details

Date Published: 23 June 2015
PDF: 9 pages
J. Biomed. Opt. 20(6) 066008 doi: 10.1117/1.JBO.20.6.066008
Published in: Journal of Biomedical Optics Volume 20, Issue 6
Show Author Affiliations
Qinqin Zhang, Univ. of Washington (United States)
Yanping Huang, Univ. of Washington (United States)
Thomas Zhang, Carl Zeiss Meditec, Inc. (United States)
Sophie Kubach, Carl Zeiss Meditec, Inc. (United States)
Lin An, Carl Zeiss Meditec, Inc. (United States)
Michal Laron, Carl Zeiss Meditec, Inc. (United States)
Utkarsh Sharma, Carl Zeiss Meditec, Inc. (United States)
Ruikang K. Wang, Univ. of Washington (United States)


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