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Journal of Biomedical Optics

High-speed intravascular spectroscopic photoacoustic imaging at 1000 A-lines per second with a 0.9-mm diameter catheter
Author(s): Yan Li; Xiaojing Gong; Chengbo Liu; Riqiang Lin; William Hau; Xiaosong Bai; Liang Song
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Paper Abstract

Intravascular spectroscopic photoacoustic technology can image atherosclerotic plaque composition with high sensitivity and specificity, which is critical for identifying vulnerable plaques. Here, we designed and engineered a catheter of 0.9 mm in diameter for intravascular photoacoustic (IVPA) imaging, smaller than the critical size of 1 mm required for clinical translation. Further, a quasifocusing photoacoustic excitation scheme was developed for the catheter, producing well-detectable IVPA signals from stents and lipids with a laser energy as low as ∼30  μJ/pulse. As a result, this design enabled the use of a low-energy, high-repetition rate, ns-pulsed optical parametric oscillator laser for high-speed spectroscopic IVPA imaging at both the 1.2-μm and 1.7-μm spectral bands for lipid detection. Specifically, for each wavelength, a 1-kHz IVPA A-line rate was achieved, ∼100-fold faster than previously reported IVPA systems offering a similar wavelength tuning range. Using the system, spectroscopic IVPA imaging of peri-adventitial adipose tissue from a porcine aorta segment was demonstrated. The significantly improved imaging speed, together with the reduced catheter size and multiwavelength spectroscopic imaging ability, suggests that the developed high-speed IVPA technology is of great potential to be further translated for in vivo applications.

Paper Details

Date Published: 22 June 2015
PDF: 7 pages
J. Biomed. Opt. 20(6) 065006 doi: 10.1117/1.JBO.20.6.065006
Published in: Journal of Biomedical Optics Volume 20, Issue 6
Show Author Affiliations
Yan Li, Shenzhen Institutes of Advanced Technology (China)
Xiaojing Gong, Shenzhen Institute of Advanced Technology (China)
Chengbo Liu, Shenzhen Institute of Advanced Technology (China)
BCMIIS (China)
Riqiang Lin, Shenzhen Institute of Advanced Technology (China)
William Hau, The Univ. of Hong Kong (China)
Xiaosong Bai, Shenzhen Institute of Advanced Technology (China)
Liang Song, Shenzhen Institute of Advanced Technology (China)
BCMIIS (China)


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