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Journal of Biomedical Optics

Screening of patients with bronchopulmonary diseases using methods of infrared laser photoacoustic spectroscopy and principal component analysis
Author(s): Yury V. Kistenev; Alexander I. Karapuzikov; Nadezhda Yu Kostyukova; Marina K. Starikova; Andrey A. Boyko; Ekaterina B. Bukreeva; Anna A. Bulanova; Dmitry B. Kolker; Dmitry A. Kuzmin; Konstantin G. Zenov; Alexey A. Karapuzikov
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Paper Abstract

A human exhaled air analysis by means of infrared (IR) laser photoacoustic spectroscopy is presented. Eleven healthy nonsmoking volunteers (control group) and seven patients with chronic obstructive pulmonary disease (COPD, target group) were involved in the study. The principal component analysis method was used to select the most informative ranges of the absorption spectra of patients’ exhaled air in terms of the separation of the studied groups. It is shown that the data of the profiles of exhaled air absorption spectrum in the informative ranges allow identifying COPD patients in comparison to the control group.

Paper Details

Date Published: 3 June 2015
PDF: 6 pages
J. Biomed. Opt. 20(6) 065001 doi: 10.1117/1.JBO.20.6.065001
Published in: Journal of Biomedical Optics Volume 20, Issue 6
Show Author Affiliations
Yury V. Kistenev, Siberian State Medical Univ. (Russia)
National Research Tomsk State Univ. (Russia)
Alexander I. Karapuzikov, Special Technologies Ltd. (Russia)
Nadezhda Yu Kostyukova, Special Technologies, Ltd. (Russia)
Marina K. Starikova, Special Technologies Ltd. (Russia)
Andrey A. Boyko, Special Technologies, Ltd. (Russia)
Ekaterina B. Bukreeva, Siberian State Medical Univ. (Russia)
Anna A. Bulanova, Siberian State Medical Univ. (Russia)
Dmitry B. Kolker, Special Technologies, Ltd. (Russia)
Novosibirsk State Univ. (Russia)
Dmitry A. Kuzmin, Siberian State Medical Univ. (Russia)
Konstantin G. Zenov, Special Technologies Ltd. (Russia)
Alexey A. Karapuzikov, Special Technologies, Ltd. (Russia)


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