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Journal of Biomedical Optics • Open Access

Photodynamic therapy: a review of applications in neurooncology and neuropathology
Author(s): Anatoly B. Uzdensky; Elena V. Berezhnaya; Vera D. Kovaleva; Marya A. Neginskaya; Mikhail Rudkovskii; Svetlana Sharifulina

Paper Abstract

Photodynamic therapy (PDT) effect is a promising adjuvant modality for diagnosis and treatment of brain cancer. It is of importance that the bright fluorescence of most photosensitizers provides visualization of brain tumors. This is successfully used for fluorescence-guided tumor resection according to the principle “to see and to treat.” Non-oncologic application of PDT effect for induction of photothrombotic infarct of the brain tissue is a well-controlled and reproducible stroke model, in which a local brain lesion is produced in the predetermined brain area. Since normal neurons and glial cells may also be damaged by PDT and this can lead to unwanted neurological consequences, PDT effects on normal neurons and glial cells should be comprehensively studied. We overviewed the current literature data on the PDT effect on a range of signaling and epigenetic proteins that control various cell functions, survival, necrosis, and apoptosis. We hypothesize that using cell-specific inhibitors or activators of some signaling proteins, one can selectively protect normal neurons and glia, and simultaneously exacerbate photodynamic damage of malignant gliomas.

Paper Details

Date Published: 7 April 2015
PDF: 7 pages
J. Biomed. Opt. 20(6) 061108 doi: 10.1117/1.JBO.20.6.061108
Published in: Journal of Biomedical Optics Volume 20, Issue 6
Show Author Affiliations
Anatoly B. Uzdensky, Southern Federal Univ. (Russia)
Elena V. Berezhnaya, Southern Federal Univ. (Russia)
Vera D. Kovaleva, Southern Federal Univ. (Russia)
Marya A. Neginskaya, Southern Federal Univ. (Russia)
Mikhail Rudkovskii, Southern Federal Univ. (Russia)
Svetlana Sharifulina, Southern Federal Univ. (Russia)


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