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Journal of Biomedical Optics

Optimal flushing agents for integrated optical and acoustic imaging systems
Author(s): Jiawen Li; Hataka Minami; Earl Steward; Teng Ma; Dilbahar Mohar; Claire Robertson; Kirk Shung; Qifa Zhou; Pranav Patel; Zhongping Chen
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Paper Abstract

An increasing number of integrated optical and acoustic intravascular imaging systems have been developed and hold great promise for accurately diagnosing vulnerable plaques and guiding atherosclerosis treatment. However, in any intravascular environment, the vascular lumen is filled with blood, a high-scattering source for optical and high-frequency ultrasound signals. Blood must be flushed away to provide clearer images. To our knowledge, no research has been performed to find the ideal flushing agent for combined optical and acoustic imaging techniques. We selected three solutions as potential flushing agents for their image-enhancing effects: mannitol, dextran, and iohexol. Testing of these flushing agents was performed in a closed-loop circulation model and <italic<in vivo</italic< on rabbits. We found that a high concentration of dextran was the most useful for simultaneous intravascular ultrasound and optical coherence tomography imaging.

Paper Details

Date Published: 18 May 2015
PDF: 8 pages
J. Biomed. Opt. 20(5) 056005 doi: 10.1117/1.JBO.20.5.056005
Published in: Journal of Biomedical Optics Volume 20, Issue 5
Show Author Affiliations
Jiawen Li, Beckman Laser Institute and Medical Clinic (United States)
Hataka Minami, Univ. of California, Irvine (United States)
Earl Steward, Univ. of California, Irvine School of Medicine (United States)
Teng Ma, The Univ. of Southern California (United States)
Dilbahar Mohar, Univ. of California, Irvine School of Medicine (United States)
Claire Robertson, Univ. of California, Irvine (United States)
Kirk Shung, The Univ. of Southern California (United States)
Qifa Zhou, The Univ. of Southern California (United States)
Pranav Patel, UC Irvine Health (United States)
Zhongping Chen, Beckman Laser Institute and Medical Clinic (United States)


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