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Journal of Biomedical Optics • Open Access

High-speed photorefractive keratectomy with femtosecond ultraviolet pulses
Author(s): Egle Danieliene; Egle Gabryte; Mikas Vengris; Osvaldas Ruksenas; Algimantas Gutauskas; Vaidotas Morkunas; Romualdas Danielius

Paper Abstract

Femtosecond near-infrared lasers are widely used for a number of ophthalmic procedures, with flap cutting in the laser-assisted in situ keratomileusis (LASIK) surgery being the most frequent one. At the same time, lasers of this type, equipped with harmonic generators, have been shown to deliver enough ultraviolet (UV) power for the second stage of the LASIK procedure, the stromal ablation. However, the speed of the ablation reported so far was well below the currently accepted standards. Our purpose was to perform high-speed photorefractive keratectomy (PRK) with femtosecond UV pulses in rabbits and to evaluate its predictability, reproducibility and healing response. The laser source delivered femtosecond 206 nm pulses with a repetition rate of 50 kHz and an average power of 400 mW. Transepithelial PRK was performed using two different ablation protocols, to a total depth of 110 and 150  μm. The surface temperature was monitored during ablation; haze dynamics and histological samples were evaluated to assess outcomes of the PRK procedure. For comparison, analogous excimer ablation was performed. Increase of the ablation speed up to 1.6  s/diopter for a 6 mm optical zone using femtosecond UV pulses did not significantly impact the healing process.

Paper Details

Date Published: 5 March 2015
PDF: 9 pages
J. Biomed. Opt. 20(5) 051037 doi: 10.1117/1.JBO.20.5.051037
Published in: Journal of Biomedical Optics Volume 20, Issue 5
Show Author Affiliations
Egle Danieliene, Akiu Gydytoju Praktika (private ophthalmological practice) (Lithuania)
Egle Gabryte, Light Conversion Ltd. (Lithuania)
Vilnius Univ. (Lithuania)
Mikas Vengris, Light Conversion Ltd. (Lithuania)
Vilnius Univ. (Lithuania)
Osvaldas Ruksenas, Vilnius Univ. (Lithuania)
Algimantas Gutauskas, Akiu Lazerines Chirurgijos Centras Ltd. (Lithuania)
Vaidotas Morkunas, Vilnius Univ. (Lithuania)
Romualdas Danielius, Light Conversion Ltd. (Lithuania)

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