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Journal of Biomedical Optics

Native fluorescence spectroscopy of blood plasma of rats with experimental diabetes: identifying fingerprints of glucose-related metabolic pathways
Author(s): Evgeny A. Shirshin; Olga P. Cherkasova; Tatiana Tikhonova; Elena Berlovskaya; Alexander V. Priezzhev; Victor Fadeev
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Paper Abstract

We present the results of a native fluorescence spectroscopy study of blood plasma of rats with experimental diabetes. It was shown that the fluorescence emission band shape at 320 nm excitation is the most indicative of hyperglycemia in the blood plasma samples. We provide the interpretation of this fact based on the changes in reduced nicotinamide adenine dinucleotide phosphate concentration due to glucose-related metabolic pathways and protein fluorescent cross-linking formation following nonenzymatic glycation.

Paper Details

Date Published: 18 February 2015
PDF: 6 pages
J. Biomed. Opt. 20(5) 051033 doi: 10.1117/1.JBO.20.5.051033
Published in: Journal of Biomedical Optics Volume 20, Issue 5
Show Author Affiliations
Evgeny A. Shirshin, Lomonosov Moscow State Univ. (Russia)
Olga P. Cherkasova, Institute of Laser Physics (Russia)
Tatiana Tikhonova, Lomonosov Moscow State Univ. (Russia)
Elena Berlovskaya, Lomonosov Moscow State Univ. (Russia)
Alexander V. Priezzhev, Lomonosov Moscow State Univ. (Russian Federation)
Victor Fadeev, Lomonosov Moscow State Univ. (Russia)


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