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Journal of Biomedical Optics

Linear-array-based photoacoustic imaging of human microcirculation with a range of high frequency transducer probes
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Paper Abstract

Photoacoustic imaging (PAI) with a linear-array-based probe can provide a convenient means of imaging the human microcirculation within its native structural context and adds functional information. PAI using a multielement linear transducer array combined with multichannel collecting system was used for in vivo volumetric imaging of the blood microcirculation, the total concentration of hemoglobin (HbT), and the hemoglobin oxygen saturation (sO2) within human tissue. Three-dimensional (3-D) PA and ultrasound (US) volumetric scans were acquired from the forearm skin by linearly translating the transducer with a stepper motor over a region of interest, while capturing two-dimensional images using 15, 21, and 40 MHz frequency transducer probes. For the microvasculature imaging, PA images were acquired at 800- and 1064-nm wavelengths. For the HbT and sO2 estimates, PA images were collected at 750- and 850-nm wavelengths. 3-D microcirculation, HbT, and sO2 maps of the forearm skin were obtained from normal subjects. The linear-array-based PAI has been found promising in terms of resolution, imaging depth, and imaging speed for in vivo microcirculation imaging within human skin. We believe that a reflection type probe, similar to existing clinical US probes, is most likely to succeed in real clinical applications. Its advantages include ease of use, speed, and familiarity for radiographers and clinicians.

Paper Details

Date Published: 23 December 2014
PDF: 7 pages
J. Biomed. Opt. 20(5) 051021 doi: 10.1117/1.JBO.20.5.051021
Published in: Journal of Biomedical Optics Volume 20, Issue 5
Show Author Affiliations
Haroon Zafar, National Univ. of Ireland, Galway (Ireland)
National Biophotonics and Imaging Platform (Ireland)
Aedán Breathnach, National Univ. of Ireland, Galway (Ireland)
National Biophotonics and Imaging Platform (Ireland)
Hrebesh M. Subhash, National Univ. of Ireland, Galway (Ireland)
Martin J. Leahy, National Univ. of Ireland, Galway (Ireland)
National Biophotonics and Imaging Platform (Ireland)
Royal College of Surgeons in Ireland (Ireland)

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