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Journal of Biomedical Optics • Open Access

Characterization of atopic skin and the effect of a hyperforin-rich cream by laser scanning microscopy
Author(s): Martina C. Meinke; Heike Richter; Anke Kleemann; Juergen M. Lademann; Kathrin Tscherch; Sascha Rohn; Christoph M. Schempp

Paper Abstract

Atopic dermatitis (AD) is a multifactorial inflammatory skin disease that affects both children and adults in an increasing manner. The treatment of AD often reduces subjective skin parameters, such as itching, dryness, and tension, but the inflammation cannot be cured. Laser scanning microscopy was used to investigate the skin surface, epidermal, and dermal characteristics of dry and atopic skin before and after treatment with an ointment rich in hyperforin, which is known for its anti-inflammatory effects. The results were compared to subjective parameters and transepidermal water loss, stratum corneum moisture, and stratum corneum lipids. Using biophysical methods, in particular laser scanning microscopy, it was found that atopic skin has distinct features compared to healthy skin. Treatment with a hyperforin-rich ointment resulted in an improvement of the stratum corneum moisture, skin surface dryness, skin lipids, and the subjective skin parameters, indicating that the barrier is stabilized and improved by the ointment. But in contrast to the improved skin surface, the inflammation in the deeper epidermis/dermis often continues to exist. This could be clearly shown by the reflectance confocal microscopy (RCM) measurements. Therefore, RCM measurements could be used to investigate the progress in treatment of atopic dermatitis.

Paper Details

Date Published: 2 December 2014
PDF: 8 pages
J. Biomed. Opt. 20(5) 051013 doi: 10.1117/1.JBO.20.5.051013
Published in: Journal of Biomedical Optics Volume 20, Issue 5
Show Author Affiliations
Martina C. Meinke, Charité Universitätsmedizin Berlin (Germany)
Heike Richter, Charité Universitätsmedizin Berlin (Germany)
Anke Kleemann, Klostermann GmbH (Germany)
Juergen M. Lademann, Charité Universitätsmedizin Berlin (Germany)
Kathrin Tscherch, Univ. Hamburg (Germany)
Sascha Rohn, Univ. Hamburg (Germany)
Christoph M. Schempp, Univ. Hospital Freiburg (Germany)

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