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Journal of Biomedical Optics • Open Access

Reflectance spectroscopy for noninvasive evaluation of hair follicle stage
Author(s): Caihua Liu; Yue Guan; Jianru Wang; Xiewei Zhong; Xiuli Liu; Dan Zhu

Paper Abstract

Hair follicle offers an excellent model for systems biology and regenerative medicine. So far, the stages of hair follicle growth have been evaluated by histological examination. In this work, a noninvasive spectroscopy was proposed by measuring the diffuse reflectance of mouse skin and analyzing the melanin value. Results show that the skin diffuse reflectance was relatively high when hair follicles were at the telogen stage and at the beginning of the anagen stage, and decreased with the progression of the anagen stage. When the hair follicle entered into the catagen stage, the diffuse reflectance gradually increased. The changes in the melanin content of skin had contrary dynamics. Substages of the hair follicle cycle could be distinguished by comparing the changes in melanin value with the histological examination. This study provided a new method for noninvasive evaluation of the hair follicle stage, and should be valuable for basic and therapeutic investigations on hair regeneration.

Paper Details

Date Published: 27 November 2014
PDF: 6 pages
J. Biomed. Opt. 20(5) 051011 doi: 10.1117/1.JBO.20.5.051011
Published in: Journal of Biomedical Optics Volume 20, Issue 5
Show Author Affiliations
Caihua Liu, Britton Chance Ctr. for Biomedical Photonics (China)
Huazhong Univ. of Science and Technology (China)
Yue Guan, Huazhong Univ. of Science and Technology (China)
Jianru Wang, Huazhong Univ. of Science and Technology (China)
Xiewei Zhong, Britton Chance Ctr. for Biomedical Photonics (China)
Huazhong Univ. of Science and Technology (China)
Xiuli Liu, Huazhong Univ. of Science and Technology (China)
Dan Zhu, Huazhong Univ. of Science and Technology (China)


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