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Journal of Biomedical Optics

Assessment of colloid response by nonlinear optical microscopy after preoperative radiochemotherapy for rectal carcinoma
Author(s): Lianhuang Li; Zhifen Chen; Xingfu Wang; Shuangmu Zhuo; Hongsheng Li; Weizhong Jiang; Guoxian Guan; Jianxin Chen
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Paper Abstract

Colloid response is a type of tumor response that occurs after preoperative radiochemotherapy for rectal carcinoma. Given its important influence on survival, the colloid response should be considered when estimating histopathological reactions. Here, multiphoton microscopy (MPM) was applied to evaluate the colloid response <italic<ex vivo</italic<. This study demonstrated that MPM has the capability to visualize the colloid response in the absence of labels and can, in particular, identify rare residual carcinomatous cells in mucin pools. These results highlight the potential of this nonlinear optical technique as a diagnostic tool for tumor response after neoadjuvant treatment.

Paper Details

Date Published: 1 December 2014
PDF: 5 pages
J. Biomed. Opt. 20(5) 051009 doi: 10.1117/1.JBO.20.5.051009
Published in: Journal of Biomedical Optics Volume 20, Issue 5
Show Author Affiliations
Lianhuang Li, Institute of Laser and Optoelectronics Technology (China)
Zhifen Chen, Fujian Medical Univ. (China)
Xingfu Wang, Fujian Medical Univ. (China)
Shuangmu Zhuo, Institute of Laser and Optoelectronics Technology (China)
Hongsheng Li, Fujian Normal Univ. (China)
Weizhong Jiang, Fujian Medical Univ. (China)
Guoxian Guan, Fujian Medical Univ. (China)
Jianxin Chen, Institute of Laser and Optoelectronics Technology (China)

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