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Journal of Biomedical Optics

Gold nanoaggregates for probing single-living cell based on surface-enhanced Raman spectroscopy
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Paper Abstract

Gold nanoparticles are delivered into living cells by transient electroporation method to obtain intracellular surface-enhanced Raman spectroscopy (SERS). The subcellular localization of gold nanoparticles is characterized by transmission electron microscopy, and the forming large gold nanoaggregates are mostly found in the cytoplasm. The SERS detection of cells indicates that this kind of gold nanostructures induces a high signal enhancement of cellular chemical compositions, in addition to less cellular toxicity than that of silver nanoparticles. These results demonstrate that rapid incorporation of gold nanoparticles by electroporation into cells has great potential applications in the studies of cell biology and biomedicine.

Paper Details

Date Published: 11 November 2014
PDF: 5 pages
J. Biomed. Opt. 20(5) 051005 doi: 10.1117/1.JBO.20.5.051005
Published in: Journal of Biomedical Optics Volume 20, Issue 5
Show Author Affiliations
Peng Lu, Fujian Normal Univ. (China)
Jing Wang, Fujian Normal Univ. (China)
Jinyong Lin, Fujian Normal Univ. (China)
Juqiang Lin, Fujian Normal Univ. (China)
Nenrong Liu, Fujian Normal Univ. (China)
Zufang Huang, Fujian Normal Univ. (China)
Buhong Li, Fujian Normal Univ. (China)
Haishan Zeng, The BC Cancer Agency Research Ctr. (Canada)
Rong Chen, Fujian Normal Univ. (China)

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