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Journal of Biomedical Optics

Photoacoustic imaging of human lymph nodes with endogenous lipid and hemoglobin contrast
Author(s): James A. Guggenheim; Thomas J. Allen; Andrew Plumb; Edward Z. Zhang; Manuel Rodriguez-Justo; Shonit Punwani; Paul C. Beard
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Paper Abstract

Lymph nodes play a central role in metastatic cancer spread and are a key clinical assessment target. Abnormal node vascularization, morphology, and size may be indicative of disease but can be difficult to visualize with sufficient accuracy using existing clinical imaging modalities. To explore the potential utility of photoacoustic imaging for the assessment of lymph nodes, images of <italic<ex vivo</italic< samples were obtained at multiple wavelengths using a high-resolution three-dimensional photoacoustic scanner. These images showed that hemoglobin based contrast reveals nodal vasculature and lipid-based contrast reveals the exterior node size, shape, and boundary integrity. These two sources of complementary contrast may allow indirect observation of cancer, suggesting a future role for photoacoustic imaging as a tool for the clinical assessment of lymph nodes.

Paper Details

Date Published: 26 May 2015
PDF: 3 pages
J. Biomed. Opt. 20(5) 050504 doi: 10.1117/1.JBO.20.5.050504
Published in: Journal of Biomedical Optics Volume 20, Issue 5
Show Author Affiliations
James A. Guggenheim, Univ. College London (United Kingdom)
Thomas J. Allen, Univ. College London (United Kingdom)
Andrew Plumb, Univ. College London (United Kingdom)
Edward Z. Zhang, Univ. College London (United Kingdom)
Manuel Rodriguez-Justo, Univ. College London (United Kingdom)
Shonit Punwani, Univ. College London (United Kingdom)
Paul C. Beard, Univ. College London (United Kingdom)

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