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Journal of Biomedical Optics

Laser beam coupling into nerve fiber myelin allows one to assess its structural membrane properties
Author(s): Nikolay P. Kutuzov; Alexey R. Brazhe; Vladimir L. Lyaskovskiy; Georgy Maksimov
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Paper Abstract

We show that myelin, the insulation wrap of nerve fibers, can couple laser light, thus behaving as a single-cell optical device. The effect was employed to map distinct myelin regions based on the coupling efficiency. Raman spectra acquisition allowed us to simultaneously understand the underlying microscopic differences in the membrane lipid ordering degree. The described method potentially provides new capabilities in myelin-associated disease studies and can be used as a handy tool for myelin structure investigation in combination with other methods.

Paper Details

Date Published: 8 May 2015
PDF: 3 pages
J. Biomed. Opt. 20(5) 050501 doi: 10.1117/1.JBO.20.5.050501
Published in: Journal of Biomedical Optics Volume 20, Issue 5
Show Author Affiliations
Nikolay P. Kutuzov, Lomonosov Moscow State Univ. (Russia)
Alexey R. Brazhe, Lomonosov Moscow State Univ. (Russia)
Vladimir L. Lyaskovskiy, All-Russian Research Institute for Optical and Physical Measurement (Russia)
Georgy Maksimov, Lomonosov Moscow State Univ. (Russia)


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