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Journal of Biomedical Optics

Optimization of irradiance for photodynamic therapy of port-wine stain
Author(s): Feng-juan Zhang; Xiao-ming Hu; Ya Zhou; Qin Li
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Paper Abstract

Controllable and effective irradiation of lesions is among the key factors that affect the potency of photodynamic therapy (PDT). An optimization method for the irradiance distribution of treatment was proposed which can be used to improve the efficacy of PDT and allow more lesions to receive the desired irradiance level in a single therapy session. With the proposed digital illumination binocular treatment system, the preferred surface normal vectors, irradiation angles, as well as area and weight coefficients of lesions can be achieved and used as characteristic parameters to optimize the irradiation direction. Two port-wine stain phantom experiments were performed. The comparison of the illumination area between preoptimization and postoptimization showed that the proposed method can effectively guide the light source control, improve the distribution of light dose, and increase the effective treatment area.

Paper Details

Date Published: 24 April 2015
PDF: 10 pages
J. Biomed. Opt. 20(4) 048004 doi: 10.1117/1.JBO.20.4.048004
Published in: Journal of Biomedical Optics Volume 20, Issue 4
Show Author Affiliations
Feng-juan Zhang, Beijing Institute of Technology (China)
Xiao-ming Hu, Beijing Institute of Technology (China)
Ya Zhou, Beijing Institute of Technology (China)
Qin Li, Beijing Institute of Technology (China)

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