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Journal of Biomedical Optics

Kidney tumor staging using surface-enhanced Raman scattering
Author(s): Sevda Mert; Emin Özbek; Alper Ötünçtemur; Mustafa Çulha
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Paper Abstract

The detection of kidney cancers at an early stage is critical for diagnosis and therapy. Surface-enhanced Raman scattering (SERS) is investigated for early detection of cancer cases from biopsy samples. The colloidal silver nanoparticles as the SERS-active nanostructures are directly mixed with homogenized tissue samples. The SERS spectra from the normal and abnormal tissue samples collected from 40 cancer patients, 28 of them at T1 stage and 12 of them at T2–T3 stages, are analyzed using principal component analysis combined linear discriminant analysis with leave-one-out cross-validation method. It is found that the diagnosis sensitivity, specificity, and total accuracy of the approach can be as high as 100%. The results suggest that SERS can be used as a potential technique for the identification of the different tumor stages.

Paper Details

Date Published: 9 April 2015
PDF: 10 pages
J. Biomed. Opt. 20(4) 047002 doi: 10.1117/1.JBO.20.4.047002
Published in: Journal of Biomedical Optics Volume 20, Issue 4
Show Author Affiliations
Sevda Mert, Yeditepe Univ. (Turkey)
Emin Özbek, Okmeydanı Education and Research Hospital (Turkey)
Alper Ötünçtemur, Okmeydanı Education and Research Hospital (Turkey)
Mustafa Çulha, Yeditepe Univ. (Turkey)

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