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Journal of Biomedical Optics • Open Access

Evaluation of cortical plasticity in children with cerebral palsy undergoing constraint-induced movement therapy based on functional near-infrared spectroscopy
Author(s): Jianwei Cao; Bilal Khan; Nathan Hervey; Fenghua Tian; Mauricio R. Delgado; Nancy J. Clegg; Linsley Smith; Heather Roberts; Kirsten Tulchin-Francis; Angela Shierk; Laura Shagman; Duncan MacFarlane; Hanli Liu; George Alexandrakis

Paper Abstract

Sensorimotor cortex plasticity induced by constraint-induced movement therapy (CIMT) in six children (10.2±2.1 years old) with hemiplegic cerebral palsy was assessed by functional near-infrared spectroscopy (fNIRS). The activation laterality index and time-to-peak/duration during a finger-tapping task and the resting-state functional connectivity were quantified before, immediately after, and 6 months after CIMT. These fNIRS-based metrics were used to help explain changes in clinical scores of manual performance obtained concurrently with imaging time points. Five age-matched healthy children (9.8±1.3 years old) were also imaged to provide comparative activation metrics for normal controls. Interestingly, the activation time-to-peak/duration for all sensorimotor centers displayed significant normalization immediately after CIMT that persisted 6 months later. In contrast to this improved localized activation response, the laterality index and resting-state connectivity metrics that depended on communication between sensorimotor centers improved immediately after CIMT, but relapsed 6 months later. In addition, for the subjects measured in this work, there was either a trade-off between improving unimanual versus bimanual performance when sensorimotor activation patterns normalized after CIMT, or an improvement occurred in both unimanual and bimanual performance but at the cost of very abnormal plastic changes in sensorimotor activity.

Paper Details

Date Published: 21 April 2015
PDF: 11 pages
J. Biomed. Opt. 20(4) 046009 doi: 10.1117/1.JBO.20.4.046009
Published in: Journal of Biomedical Optics Volume 20, Issue 4
Show Author Affiliations
Jianwei Cao, The Univ. of Texas at Arlington (United States)
Bilal Khan, The Univ. of Texas at Dallas (United States)
Nathan Hervey, The Univ. of Texas at Arlington (United States)
Fenghua Tian, The Univ. of Texas at Arlington (United States)
Mauricio R. Delgado, Texas Scottish Rite Hospital for Children (United States)
Univ. of Texas Southwestern Medical Ctr. at Dallas (United States)
Nancy J. Clegg, Texas Scottish Rite Hospital for Children (United States)
Linsley Smith, Texas Scottish Rite Hospital for Children (United States)
Heather Roberts, Texas Scottish Rite Hospital for Children (United States)
Kirsten Tulchin-Francis, Texas Scottish Rite Hospital for Children (United States)
Angela Shierk, Texas Scottish Rite Hospital for Children (United States)
Laura Shagman, The Univ. of Texas at Dallas (United States)
Duncan MacFarlane, The Univ. of Texas at Dallas (United States)
Hanli Liu, The Univ. of Texas at Arlington (United States)
George Alexandrakis, The Univ. of Texas at Arlington (United States)


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