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Journal of Biomedical Optics • Open Access

Organosilicon phantom for photoacoustic imaging
Author(s): Cinzia Avigo; Nicole Di Lascio; Paolo Armanetti; Claudia Kusmic; Lucia Cavigli; Fulvio Ratto; Sandro Meucci; Cecilia Masciullo; Marco Cecchini; Roberto Pini; Francesco Faita; Luca Menichetti

Paper Abstract

Photoacoustic imaging is an emerging technique. Although commercially available photoacoustic imaging systems currently exist, the technology is still in its infancy. Therefore, the design of stable phantoms is essential to achieve semiquantitative evaluation of the performance of a photoacoustic system and can help optimize the properties of contrast agents. We designed and developed a polydimethylsiloxane (PDMS) phantom with exceptionally fine geometry; the phantom was tested using photoacoustic experiments loaded with the standard indocyanine green dye and compared to an agar phantom pattern through polyethylene glycol-gold nanorods. The linearity of the photoacoustic signal with the nanoparticle number was assessed. The signal-to-noise ratio and contrast were employed as image quality parameters, and enhancements of up to 50 and up to 300%, respectively, were measured with the PDMS phantom with respect to the agar one. A tissue-mimicking (TM)-PDMS was prepared by adding TiO2 and India ink; photoacoustic tests were performed in order to compare the signal generated by the TM-PDMS and the biological tissue. The PDMS phantom can become a particularly promising tool in the field of photoacoustics for the evaluation of the performance of a PA system and as a model of the structure of vascularized soft tissues.

Paper Details

Date Published: 20 April 2015
PDF: 7 pages
J. Biomed. Opt. 20(4) 046008 doi: 10.1117/1.JBO.20.4.046008
Published in: Journal of Biomedical Optics Volume 20, Issue 4
Show Author Affiliations
Cinzia Avigo, Istituto di Fisiologia Clinica (Italy)
Nicole Di Lascio, Istituto di Fisiologia Clinica (Italy)
Scuola Superiore Sant’Anna (Italy)
Paolo Armanetti, Univ. di Pisa (Italy)
Claudia Kusmic, Istituto di Fisiologia Clinica (Italy)
Lucia Cavigli, Istituto di Fisica Applicata Nello Carrara (Italy)
Fulvio Ratto, Istituto di Fisica Applicata Nello Carrara (Italy)
Sandro Meucci, Scuola Normale Superiore (Italy)
Cecilia Masciullo, Lab. NEST (Italy)
Marco Cecchini, Lab. NEST (Italy)
Roberto Pini, Istituto di Fisica Applicata Nello Carrara (Italy)
Francesco Faita, Istituto di Fisiologia Clinica (Italy)
Luca Menichetti, Istituto di Fisiologia Clinica (Italy)
Fondazione CNR/Regione Toscana G. Monasterio (Italy)

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