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Journal of Biomedical Optics

Multimodal optical measurement <italic<in vitro</italic< of surface deformations and wall thickness of the pressurized aortic arch
Author(s): Katia Genovese; Jay D. Humphrey
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Paper Abstract

Computational modeling of arterial mechanics continues to progress, even to the point of allowing the study of complex regions such as the aortic arch. Nevertheless, most prior studies assign homogeneous and isotropic material properties and constant wall thickness even when implementing patient-specific luminal geometries obtained from medical imaging. These assumptions are not due to computational limitations, but rather to the lack of spatially dense sets of experimental data that describe regional variations in mechanical properties and wall thickness in such complex arterial regions. In this work, we addressed technical challenges associated with <italic<in vitro</italic< measurement of overall geometry, full-field surface deformations, and regional wall thickness of the porcine aortic arch in its native anatomical configuration. Specifically, we combined two digital image correlation-based approaches, standard and panoramic, to track surface geometry and finite deformations during pressurization, with a 360-deg fringe projection system to contour the outer and inner geometry. The latter provided, for the first time, information on heterogeneous distributions of wall thickness of the arch and associated branches in the unloaded state. Results showed that mechanical responses vary significantly with orientation and location (e.g., less extensible in the circumferential direction and with increasing distance from the heart) and that the arch exhibits a nearly linear increase in pressure-induced strain up to 40%, consistent with other findings on proximal porcine aortas. Thickness measurements revealed strong regional differences, thus emphasizing the need to include nonuniform thicknesses in theoretical and computational studies of complex arterial geometries.

Paper Details

Date Published: 13 April 2015
PDF: 11 pages
J. Biomed. Opt. 20(4) 046005 doi: 10.1117/1.JBO.20.4.046005
Published in: Journal of Biomedical Optics Volume 20, Issue 4
Show Author Affiliations
Katia Genovese, Univ. degli Studi della Basilicata (Italy)
Jay D. Humphrey, Yale Univ. (United States)

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