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Journal of Biomedical Optics

Research on the change of complex refractive index of porcine muscle during natural dehydration
Author(s): Zhichao Deng; Jin Wang; Yuanze Liu; Qing Ye; Tengqian Sun; Wen-Yuan Zhou; Jian-Chun Mei; Chun-Ping Zhang; Jianguo Tian
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Paper Abstract

The physical changes of tissue are complicated to evaluate during optical clearing (OC) treatment. Monitoring the changes of optical parameters, including the complex refractive index (CRI), helps people better understand the OC process. From the imaginary part of CRI, we can deduce the extinction coefficient of tissue. Based on the total internal reflection method, the time-dependent CRI of porcine muscle during natural dehydration is well determined. Results show that the real RI increases continuously with the increase of dehydration time, whereas the extinction coefficient initially increases and then decreases. Finally, the extinction coefficient becomes much smaller than the initial value, which demonstrates that better tissue optical clarity is obtained. The change tendency of the extinction coefficient of tissue is used to qualitatively explain the dynamic change of transmittance of a natural dehydrated tissue. Consequently, CRI, especially its imaginary part, is a very useful optical parameter by which to evaluate the OC effect.

Paper Details

Date Published: 13 April 2015
PDF: 5 pages
J. Biomed. Opt. 20(4) 045001 doi: 10.1117/1.JBO.20.4.045001
Published in: Journal of Biomedical Optics Volume 20, Issue 4
Show Author Affiliations
Zhichao Deng, Nankai Univ. (China)
Jin Wang, Nankai Univ. (China)
Yuanze Liu, Nankai Univ. (China)
Qing Ye, Nankai Univ. (China)
Tengqian Sun, Nankai Univ. (China)
Wen-Yuan Zhou, Nankai Univ. (China)
Jian-Chun Mei, Nankai Univ. (China)
Chun-Ping Zhang, Nankai Univ. (China)
Jianguo Tian, Nankai Univ. (China)

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