Share Email Print

Journal of Biomedical Optics

Blood typing using microstructured waveguide smart cuvette
Format Member Price Non-Member Price
PDF $20.00 $25.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

We introduce a sensitive method that allows one to distinguish positive and negative agglutination reactions used for blood typing and determination of Rh affinity with a high precision. The method is based on the unique properties of photonic crystal waveguides, i.e., microstructured waveguides (MSWs). The transmission spectrum of an MSW smart cuvette filled by a specific or nonspecific agglutinating serum depends on the scattering, refractive, and absorptive properties of the blood probe. This concept was proven in the course of a laboratory clinical study. The obtained ratio of the spectral-based discrimination parameter for positive and negative reactions (I+/I−) was found to be 16 for standard analysis and around 2 for used sera with a weak activity.

Paper Details

Date Published: 13 April 2015
PDF: 3 pages
J. Biomed. Opt. 20(4) 040503 doi: 10.1117/1.JBO.20.4.040503
Published in: Journal of Biomedical Optics Volume 20, Issue 4
Show Author Affiliations
Anastasiya A. Zanishevskaya, SPE LLC "NGT" (Russia)
N.G. Chernyshevsky Saratov State Univ. (Russia)
Andrey A. Shuvalov, SPE LLC "NGT" (Russia)
N.G. Chernyshevsky Saratov State Univ. (Russia)
Yulia S. Skibina, SPE LLC "NGT" (Russian Federation)
N.G. Chernyshevsky Saratov State Univ. (Russian Federation)
Valery V. Tuchin, N.G. Chernyshevsky Saratov State Univ. (Russian Federation)
Institute of Precise Mechanics and Control (Russian Federation)
Tomsk State Univ. (Russian Federation)

© SPIE. Terms of Use
Back to Top